It is estimated that protamine will reverse up to about 60% to 75% of anti-Xa activity….Enoxaparin (Lovenox®) Time Since Enoxaparin Dose Can you reverse enoxaparin?įor both enoxaparin and dalteparin, protamine does not provide a complete reversal of anti-Xa activity. If the LMW heparin dose has been given within 3-4 hours give 1 mg protamine/1 mg of enoxaparin dose. If immediate reversal is required protamine sulfate will result in partial neutralization. Termination of the SQ injection generally will terminate the anticoagulant effect.

What is the antidote for heparin and enoxaparin? 1 What is the antidote for heparin and enoxaparin?.Hepatic Dose : No dose adjustment recommended. Dose as in normal renal functionĭialysed. Renal Dose : Dose in Renal Impairment GFR (mL/min)ĭose in Patients undergoing Renal Replacement Therapies No significant interactions are known other than antagonism of coumarin anticoagulants. Neonates: In infants (particularly premature babies), excessive doses of vitamin K analogs during the first few days of life may cause hyperbilirubinemia this in turn may result in severe hemolytic anemia, hemoglobinuria, kernicterus, leading to brain damage or even death.

Large doses of vitamin K or its analogues may further depress liver function in patients with severe hepatic disease and thereby further decrease the concentration of prothrombin. Pain, swelling, and tenderness at the injection site may occur. Bronchospasm, shock, cardiac and/or respiratory arrest may also occur.

Transient flushing sensations and peculiar sensations of taste have been observed following phytonadione injection as well as rare instances of dizziness, rapid and weak pulse, profuse sweating, brief hypotension, dyspnea, and cyanosis. Alternatively, 10 mg IV, IM or subcutaneously may be administered.

Vitamin k antidote for warfarin